Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Croissant, J., Chaix, A., Mongin, O., Wang, M., Clément, S., Raehm, L., … Zink, J. I. (2014). Two-photon-triggered drug delivery via fluorescent nanovalves. Small, 10(9), 1752–1755. https://doi.org/10.1002/smll.201400042
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