Abstract
Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 μg/ml, respectively, and the MIC range is 1-16 μg/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC 50 and MIC90 of 2 and 8 μg/ml, respectively.
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Khan, S., Singhal, S., Mathur, T., Upadhyay, D. J., & Rattan, A. (2007). Antifungal potential of disulfiram. Japanese Journal of Medical Mycology, 48(3), 109–113. https://doi.org/10.3314/jjmm.48.109
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