Asteltoxins with antiviral activities from the marine sponge-Derived fungus aspergillus sp. Scsio xws02f40

Abstract

Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge-derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1-7) were determined by the extensive 1D- And 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC50 values of 6.2 ± 0.08 and 8.9 ±0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC50value of 3.5 ± 1.3 μM.