Nanoparticulate system for cancer therapy: An updated review

Abstract

Now a day, pharmaceutical nanotechnology developed as most emerging branch in the field of pharmacy. Nanotechnology refers the art of creation and utilization of materials in nano-scale formulation. These nano-formulations may used in treatment of various life threading disease like cancer. Due to the advantage of their nano size and shape, nano-formulation have been shown to be favorable drug delivery system and may be useful for encapsulating and conjugating of drugs with enabling of most precise tumor targeting and controlled release. Nanoparticle drug delivery system have several advantages such as enhanced intracellular infiltration, hydrophobic solubility, and drug circulation time and also reduce non specific uptake and toxic effect for cancer therapy. A large number of nanoparticle technologies have been developed for cancer treatment to improve the therapeutic efficacy and safety for anticancer drugs. In this paper, we review the most significant advancement in pharmaceutical nanotechnologies with methods of preparation and their use in drug delivery for cancer therapy.