Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis

Abstract

Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α, 20β-epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol (1) and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β-epoxy- 11(15→1)abeotax-11-ene-5α,13α-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro. © 2009 Verlag der Zeitschrift für Naturforschung.