DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM

Abstract

At present scenario colon specific drug delivery has gained increased importance. Colon drug delivery system not only used for the treatment of local diseases, associated with the colon but also it is a potential site for systemic delivery of therapeutic drug. Albendazole is a benzimidazole carbamate broad spectrum oral anthelmetic drug. It is poorly water soluble and it undergoes extensive metabolism in the intestine and liver.  Different batches of Albendazole microcapsules were prepared using different concentration of polymers like Eudragit RS-100, chitosan, HPMC. The microcapsules were then evaluated for micromeritic properties, percentage yield, incorporation efficiency, drug content. In vitro dissolution profile of each formulation was determined by employing USP XXIII rotating basket method. Google Scholar