Antimalarial activity of some Kenyan medicinal plants

Abstract

This paper describes the in vitro antimalarial activity of eight species of plants popularly used traditionally to treat malaria in Kenya. Organic and aqueous extracts from different parts of the plants were tested. Generally, a stronger antimalarial activity was observed in the organic extracts. The most active extracts were of Vernonia brachycalyx O. Hoffm. Schreber. (Compositae) leaves which showed an IC50 of 6.6 μg/ml for methylene chloride: ethyl acetate (1:1) extracts, while the aqueous and more polar methanolic extracts gave IC50 values of 29.6 and 30 μg/ml, respectively. The findings of this study support the use of this plant as a traditional remedy for malaria. The rest of the plants tested gave IC50 values between 30-100 μg/ml.