Endothelin-1 in cerebrospinal fluid in elderly patients with hypertension and dementia

Abstract

Endothelin-1, a potent endothelium-derived vasoconstrictive peptide, is also known to exist in the central nervous system. We determined endothelin- 1-like immunoreactivity in cerebrospinal fluid by a radioimmunoassay in 32 normotensive or hypertensive elderly subjects (79±8 years old) with or without multi-infarction dementia. The mean value of endothelin-1-like immunoreactivity in cerebrospinal fluid was significantly (P <140/90 mm Hg, n=23, 79±8 years old). The value of endothelin-1-like immunoreactivity in cerebrospinal fluid was significantly (P