State variation in the receipt of a contralateral prophylactic mastectomy amongwomen who received a diagnosis of invasive unilateral early-stage breast cancer in the United States, 2004-2012

Abstract

IMPORTANCE The use of contralateral prophylactic mastectomies (CPMs) among patients with invasive unilateral breast cancer has increased substantially during the past decade in the United States despite the lack of evidence for survival benefit. However, whether this trend varies by state or whether it is correlated with changes in proportions of reconstructive surgery among these patients is unclear. OBJECTIVE To determine state variation in the temporal trend and in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surgery. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study of 1.2 millionwomen 20 years of age or older diagnosed with invasive unilateral early-stage breast cancer and treated with surgery from January 1, 2004, through December 31, 2012, in 45 states and the District of Columbia as compiled by the North American Association of Central Cancer Registries. Data analysis was performed from August 1, 2015, to August 31, 2016. EXPOSURE Contralateral prophylactic mastectomy. MAIN OUTCOMES AND MEASURES Temporal changes in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surgery by age and state, overall and in relation to changes in the proportions of those who underwent reconstructive surgery. RESULTS Among the 1 224 947women with early-stage breast cancer treated with surgery, the proportion who underwent a CPM nationally increased between 2004 and 2012 from 3.6% (4013 of 113001) to 10.4%(12 890 of 124 231) for those 45 years or older and from 10.5%(1879 of 17 862) to 33.3%(5237 of 15 745) for those aged 20 to 44 years. The increasewas evident in all states, although the magnitude of the increase varied substantially across states. For example, amongwomen 20 to 44 years of age, the proportion who underwent a CPM from 2004-2006 to 2010-2012 increased from 14.9%(317 of 2121) to 24.8%(436 of 1755) (prevalence ratio [PR], 1.66; 95%CI, 1.46-1.89) in New Jersey compared with an increase from 9.8%(162 of 1657) to 32.2%(495 of 1538) (PR, 3.29; 95%CI, 2.80-3.88) in Virginia. In this age group, CPM proportions for the period from 2010 to 2012were over 42%in the contiguous states of Nebraska, Missouri, Colorado, Iowa, and South Dakota. From 2004 to 2012, the proportion of reconstructive surgical procedures amongwomen aged 20 to 44 years whowere diagnosed with early-stage breast cancer and received a CPM increased in many states; however, it did not correlate with the proportion ofwomen who received a CPM. CONCLUSIONS AND RELEVANCE The increase in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surgery varied substantially across states. Notably, in 5 contiguous Midwest states, nearly half of young women with invasive early-stage breast cancer underwent a CPM from 2010 to 2012. Future studies should examine the reasons for the geographic variation and increasing trend in the use of CPMs.