Abstract
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
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Ullrich, A., Chai, Y., Pistorius, D., Elnakady, Y. A., Herrmann, J. E., Weissman, K. J., … Müller, R. (2009). Pretubulysin, a potent and chemically accessible tubulysin precursor from angiococcus disciformis. Angewandte Chemie - International Edition, 48(24), 4422–4425. https://doi.org/10.1002/anie.200900406
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