Novel Topical Drug Delivery Systems in Ophthalmic Applications

Abstract

This book will cover dosage form innovations in an interdisciplinary manner. Chapters may range from the development of new dosage forms or new dosage forms for previously marketed drugs to evaluation of their performance in dissolution experiments, animal models/humans, or a correlation of these. Many oral dosage forms are now extended release formulations in order to increase compliance by reducing the number of capsules/tablets that must be taken each day. Nasal and buccal delivery systems allow rapid absorption of acutely acting pharmaceuticals and allow for by-passing first-pass metabolism in gut and liver. Transdermal systems allow slow release of potent pharmaceuticals over longer periods of time, but adhesion and dermal irritancy are often challenges with these delivery methods. Topical application of drugs allow for action on the skin itself or for systemic delivery. Drug delivery to the eye, especially for drugs where systemic exposure should be avoided has been an ongoing challenge. BT - Dosage Forms