Automatic multisyringe flow injection system for the spectrophotometric determination of tinidazole in pharmaceutical preparations

Abstract

A multisyringe flow injection analysis (MSFIA) method for the determination of tinidazole (TNZ) in pharmaceutical preparations was developed. TNZ concentrations were determined by spectrophotometric detection at 374 nm wavelength using a light emitting diode (LED). The MSFIA parameters were optimized. Under the optimized experimental conditions, a linear dynamic range from 2 to 56 mg L-1 TNZ, a 3σ detection limit of 0.3 mg L -1, and a 10σ quantification limit of 1.2 mg L-1 were obtained. The relative standard deviation (%R.S.D.) at 2, 28 and 56 mg L-1 was 2.3, 1.4 and 0.9%, respectively (n = 10). A sample throughput of 76 determinations/h was achieved.