Objective To conduct a systematic review and meta-analysis of the effectiveness of Laser Therapy in the prevention of oral mucositis (OM) in patients undergoing oncotherapy. Methods To this systematic review and meta-analysis a search was performed in MEDLINE, LILACS and Cochrane using the keywords "laser therapy" and "Oral mucostitis." The case-control studies included were submitted to odds ratio (OR) analysis, which the cut-off point for statistic calculation was OM grade > 3. We carried out a meta-analysis by BioEstat 5.0, using the Random Effect DerSimonian-Laird statistical analysis. Results Twelve (studies were included in this systematic review, and the meta-analysis of seven of them showed that LT in patients undergoing oncotherapy is approximately nine times more effective in the prevention of OM grade > 3 than in patients without laser treatment (OR: 9,5281, confidence interval 95% 1,447-52,0354, p = 0,0093. Conclusion These data demonstrated significant prophylatic effect of OM grade > 3 in patients undergoing LT. Further studies, with larger sample sizes, are needed for better evaluation of the prophylatic effect of OM grade > 3 by LT. © 2013 Elsevier Editora Ltda. All rights reserved.
CITATION STYLE
Figueiredo, A. L. P., Lins, L., Cattony, A. C., & Falcão, A. F. P. (2013). Laser terapia no controle da mucosite oral: um estudo de metanálise. Revista Da Associacao Medica Brasileira, 59(5), 467–474. https://doi.org/10.1016/j.ramb.2013.08.003
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