Metastatic granulosa-cell tumor in the liver: Cytopathologic findings and staining with inhibin

Abstract

Adult granulosa-cell tumor (AGCT) is an uncommon ovarian malignancy. Rarely, hepatic metastasis of this tumor may present a difficult cytologic diagnosis when such a lesion is aspirated. This case report elaborates the cytopathologic features of AGCT in the liver aspirate of a 60-yr-old woman. Correlation with histopathology and intraoperative touch-imprint cytology of the subsequent hepatic resection is also presented. The role of immunoperoxidase studies especially utilizing inhibin is also highlighted.