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Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Molecular Therapy (2019) 27(2) 411-423
DOI: 10.1016/j.ymthe.2018.11.016
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Abstract

Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.

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Milbreta, U., Lin, J., Pinese, C., Ong, W., Chin, J. S., Shirahama, H., … Chew, S. Y. (2019). Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination. Molecular Therapy, 27(2), 411–423. https://doi.org/10.1016/j.ymthe.2018.11.016

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