Impact of ertapenem on antimicrobial resistance in a sentinel group of Gram-negative bacilli: A 6 year antimicrobial resistance surveillance study

Abstract

Objectives: To determine the association between ertapenem and resistance of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii-calcoaceticus complex to different antimicrobials while adjusting for relevant hospital factors. Methods: This was a retrospective time-series study conducted at a tertiary care centre fromSeptember 2002 to August 2008. The specific impact of ertapenem on the resistance of these Gram-negative bacilli (GNB) was assessed by multiple linear regression analysis, adjusting for the average length of stay, rate of hospital-acquired infections and use of 10 other antimicrobials, including type 2 carbapenems. Results: Unadjusted analyses revealed significant increases over the duration of the study in the number of GNB resistant to meropenem/imipenem among 1000 isolates each of E. coli (0.46±0.22, P<0.05), P. aeruginosa (6.26±2.26, P<0.05), K. pneumoniae (8.06±1.50, P<0.0005) and A. baumannii-calcoaceticus complex (25.39±6.81, P<0.0005). Increased resistance to cefepime (and other extended-spectrum cephalosporins) was observed in E. coli (9.55±1.45, P<0.0005) and K. pneumoniae (15.21±2.42, P<0.0005). A. baumannii-calcoaceticus complex showed increased resistance to all antimicrobials except amikacin. After controlling for confounders, ertapenem was not significantly associated (P>0.05) with changes in resistance for any pathogen/antimicrobial combination. Conclusions: After controlling for confounders, ertapenem was not associated with changes in resistance in a group of sentinel GNB, although significant variations in resistance to different antimicrobials were observed in the unadjusted analyses. These results emphasize the importance of implementation of local resistance surveillance platforms and stewardship programmes to combat the global emergence and spread of antimicrobial resistance.