Structural analysis of antibiotic INA 9301 from Amycolatopsis orientalis

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Abstract

The dalbaheptide antibiotic INA 9301 was isolated from a culture of Amycolatopsis orientalis. By using a combination of mass spectrometry and NMR spectroscopy, INA 9301 was assessed as N,N-dimethylvancomycin. Detailed 13C NMR characteristics of INA9301 in D2O and DMSO-d 6 are presented, together with 2D 1H-1H ROESY and 1H-13C gHMBC data, which confirmed the configurations of the asymmetric centers and spatial conformational shape of the molecule in aqueous solution.

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Shashkov, A. S., Tsvetkov, D. E., Grachev, A. A., Lapchinskaia, O. A., Lavrova-Balashova, M. F., Ponomarenko, V. I., … Nifantiev, N. E. (2008). Structural analysis of antibiotic INA 9301 from Amycolatopsis orientalis. Natural Product Communications, 3(10), 1631–1638. https://doi.org/10.1177/1934578x0800301010

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