Potential of n-hexane and chloroform extracts from Melochia umbellata (Houtt) Stapf var bark. Visenia as dengue antivirus

Abstract

A study was conducted on the identification of the group of compounds from from n-hexane and chloroform extract of bark of M. umbelatta (Houtt.) Stapf var. Vicenia (Houtt.) and its activity test against dengue antiviral causes dengue hemorrhagic fever (DHF). The method used through several stages are maceration gradually starting from n-hexane and then followed chloroform, to stem bark powder M. umbelatta (Houtt.) Stapf var. Vicenia (Houtt.). Phytochemical test was done to know the group of compounds in each extract. In both extracts tested its activity against dengue virus. From the phytochemical test it is known that the n-hexane extract contain terpenoid, steroids and alkaloids, while in chloroform extract contain of steroids and alkaloids. From this study it was found that n-hexane and chloroform extracts were very active against dengue virus with IC50 values of 2.39 and 2.34 μg/mL. Thus, n-hexane and chloroform extracts can be used to help cure of Dengue Fever (DHF) disease.