Trauma-associated growth of suspected dormant micrometastasis

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Background: Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. Case presentation: We describe a patient with non-small lung cancer who had a rapid tumor growth and recurrence at a minor trauma site of his skull bone. Conclusion: This case is an illustration of the phenomenon of tumor growth after trauma or surgery and its associated cellular mechanisms. This phenomenon deserves further investigation and study. © 2005 El Saghir et al; licensee BioMed Central Ltd.




El Saghir, N. S., Elhajj, I. I., Geara, F. B., & Hourani, M. H. (2005). Trauma-associated growth of suspected dormant micrometastasis. BMC Cancer, 5.

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