EB1 levels are elevated in ascorbic acid (AA)-stimulated osteoblasts and mediate cell-cell adhesion-induced osteoblast differentiation

Abstract

Background: EB1 is a microtubule (MT) plus-end-binding protein known to influence MT stability. Results: EB1 is up-regulated in osteoblasts and is required for bone cell differentiation. Conclusion: EB1 affects-catenin stability and cooperates at cell-cell adhesion sites to influence gene expression. Significance: Learning how peripherally targeted proteins interact at cell-cell contact sites is crucial for understanding developmental processes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.