Liver functional behavior during thyrotoxicosis: A review

Abstract

Thyroid and liver are among two vital and important organs which are interrelated in health and disease. The cooperation of thyroid and liver is extremely vital for a proper functional behavior for both thyroid and liver. Liver crucial role in the basic metabolic rate, growth and development is due to the liver ability to transfer the thyroid hormone and deliver it to the various organs intracellular due to thyroid hormone transporting system which is mediated by the liver. Thyrotoxicosis defined as the clinical manifestation of hyperthyroidism, a symptom with various adverse effects on the liver, heart, vascular, nervous and gastrointestinal systems. There are many reports demonstrating the negative side effect of hyperthyroidism on liver function tests which occur due to the accompanying clinical manifestation of thyrotoxicosis. In severe form of hyperthyroidism in addition to liver biochemical alteration and elevated liver enzymes, damages to hepatocytes will occur. Therefore it is strongly recommended that subjects with either of hyperthyroid or liver dysfunction should be carefully examined simultaneously for both organs to have a clear cut diagnosis and to assist the patient with proper therapeutically treatments. © 2013 Asian Network for Scientific Information.