Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929

Abstract

The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be 1α-hydroxy- 3α-(4′-oxoundec-(5′E)-enyl)-pyrrolizidine and 1β-hydroxy-3α-(4′-oxoundec-(5′E)-enyl)-pyrrolizidine, respectively, by comparison with spectral data of synthetic compounds. © Japan Antibiotics Research Association.