Abstract
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 × 10-8 in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies. © 2008 Nature Publishing Group.
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CITATION STYLE
Van Es, M. A., Van Vught, P. W. J., Blauw, H. M., Franke, L., Saris, C. G. J., Van Den Bosch, L., … Van Den Berg, L. H. (2008). Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nature Genetics, 40(1), 29–31. https://doi.org/10.1038/ng.2007.52
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