Aims/hypothesis Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estimated. Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation in individuals aged 1-81 years.
CITATION STYLE
Cnop, M., Hughes, S. J., Igoillo-Esteve, M., Hoppa, M. B., Sayyed, F., Van De Laar, L., … Clark, A. (2010). The long lifespan and low turnover of human islet beta cells estimated by mathematical modeling of lipofuscin accumulation. Diabetologia, 53(2), 321–330. https://doi.org/10.1007/s00125-009-1562-x
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