Critical Analysis of Risk Factors Associated with Depression Among Patients with Chronic Kidney Disease: A Systematic Review

Abstract

ARTICLE INFO abstract Background: Chronic kidney disease (CKD) is progressive and advance medical condition in which the kidneys fail to perform their primary functions. The occurrence of CKD is on the increase globally which made it a public health issue. Depression among CKD patients is a complex and common phenomenon. The complexity of depression in CKD is associated with the similarities between depressive and uremic symptoms. Aim: The aim of this study is to conduct a critical and systematic analysis with a view to reviewing studies in order to identify the risk factors that are associated with depression in CKD. Methods: The study design is a systematic review in which 648 articles were accessed and evaluated. During the course screening and evaluation15 primary articles relevant to the research question were selected and appraised using quality appraisal framework. During the quality appraisal 4 primary articles were excluded due to low quality. Findings: Of the 11 primary articles included, 20 risk factors relevant to the research question were identified in which 18 risk factors were significant while, 2 were not significant. Narrative analysis of data was conducted because the included studies are heterogeneous. Conclusion: Depression is common among CKD patients and is associated with variety of significant risk factors.