EFFECT OF NANOPARTICLES OF SILVER IN ARGOVIT PREPARATION ON ANTIBIOTIC RESISTANCE OF BACTERIA IN COW MASTITIS TREATMENT

Abstract

In the diagnosis of subclinical, serous and catarral mastitis of cows a wide range of microorganisms has been isolated, including the genera Streptococcus (Str. disgalactiae, Str. agalactiae, Str. pyogenes), Staphylococcus (St. aureus, St. epidermidis) и E. coli. When treating cows with mastitis with argovit, the average duration of treatment for animals was2.9 +0.1, 3.3 + 0.3, 4.1 +0,2 days, which is 1.6, 1.9, 1.8 times less compared with the drug spectromast in the control group. The effect of argovit containing silver nanoparticles on antibiotic sensitivity in selected microflora in the treatment of subclinical, serous and catarrhal mastitis of cows was studied. Studies conducted to determine the antibiotic sensitivity of isolated microorganisms after the treatment of mastitis of cows showed the dependence of the results, both on the drug used and on the clinical form of the disease. It has been established that the use of spectromast causes a pronounced decrease in19 (76%) preparations with subclinical, 24 (96%) serous and 23 (92%) catarrhal mastitis. It was also noted that with the development of the pathological process, an increase in the appearance of previously absent resistance to antibacterial drugs was observed with subclinical6 (24%), serous 7 (28%), catarrhal 8 (32%) mastitis of the cows. While using argovit, an increase in antibiotic sensitivity to 21 drugs (84%) in subclinical, 24(96%) in serous and 23 (92%) catarrhal mastitis was revealed. In the treatment of subclinical mastitis in the experimental group, a slight decrease was observed for 4 (16%) drugs