Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability

4Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Diabetes mellitus (DM) is a highly prevalent disease affecting almost 10% of the world population; it is characterized by acute and chronic conditions. Diabetic patients have twenty-five times higher risk of going blind and developing cataracts early than the general population. Alpha-lipoic acid (LA) is a highly valuable natural antioxidant for the prevention and treatment of ophthalmic complications, such as diabetic keratopathy and retinopathy. However, its applicability is limited due to its low solubility in water; therefore, suitable systems are required for its formulation. In this work we developed an erodible insert based on Eudragit E100 (E PO) and Lipoic Acid (LA) for the delivery of this compound for the preventive treatment of ocular diseases especially in diabetic patients. Film evaluation was carried out by mechanical and thermal properties, mucoadhesivity, drug release, dynamic light scattering and corneal permeability as the concentration of LA increased. It was shown that upon LA release, it forms nanoparticles in combination with E PO that favor corneal permeation and LA retention in the cornea. These E PO-LA films also resulted non-irritable hence they are promising for their application in the treatment of ocular diseases.

Cite

CITATION STYLE

APA

Bierbrauer, K. L., Comini, L. R., Leonhard, V., Escobar Manzanelli, M. A., Castelli, G., Farfán, S., … Beltramo, D. M. (2023). Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability. Polymers, 15(7). https://doi.org/10.3390/polym15071793

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free