Caroténoïdes et vitamine A actualités

Abstract

The knowledge base in carotenoid research has increased and it leads to a better understanding of the physicochemical and biological properties of beta-carotene and other carotenoids, notably their metabolism in animals and humans, their antioxidant properties, their effects on Gap Junctions communications and their gene actions. Carotenoids demonstrated significant effects in human disease processes and large-scale clinical trials tested the activities of supplemental beta-carotene on the risk for chronic diseases such as cancer (ATBC, CARET, and PHS). Surprising results of the ATBC and CARET trials (enhanced risk for developing lung cancer among heavy smokers or asbestos workers) signal the need for further research. Many questions remain unanswered. Have we to rethink the field from ground zero ? Some explanations, and reflexions on experiments that remain to be done are suggested here.