Filling the gap: Micro-C accesses the nucleosomal fiber at 100-1000 bp resolution

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Abstract

The fine three-dimensional structure of the nucleosomal fiber has remained elusive to genome-wide chromosome conformation capture (3C) approaches. A new study mapping contacts at the single nucleosome level (Micro-C) reveals topological interacting domains along budding yeast chromosomes. These domains encompass one to five consecutive genes and are delimited by highly active promoters.

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Mozziconacci, J., & Koszul, R. (2015). Filling the gap: Micro-C accesses the nucleosomal fiber at 100-1000 bp resolution. Genome Biology, 16(1). https://doi.org/10.1186/s13059-015-0744-8

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