A synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)-hexylthiol. A ligand for conjugation with fluorescent cadmium selenide/zinc sulfide core/shell nanocrystals and biological imaging

Abstract

The synthesis of 6-(2,5-dimethoxy-4-(2-aminopropyl)phenyl)hexylthiol, an (agonist with a very high affinity for the 5HT)2A serotonin receptor subtype is reported. This agonist was designed to be attached to highly fluorescent cadmium selenide/zinc sulfide core/shells via a thiol at the end of a linker arm. This conjugate has applications in biological assays and biological imaging.