Phenol Sensing Studies by 4-Aminoantipyrine Method-A Review

Abstract

4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample. In this review, we discuss the usage of 4-aminoantipyrine as analytical reagent for the identification and estimation of phenolic compounds present in any of the samples reported. This review focuses on the use of 4-aminoantipyrine in phenol sensing studies from early 1980s to till date