Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA through pi-pi stacking interaction.

Abstract

DNA fragments of d(TTAG(n)) (n = 3-5) form all-parallel G-quadruplexed structure in the presence of K+. We found that G-quadruplexed d(TTAG(n)) forms dimer through end-to-end stacking of the 3'-terminal G-tetrads. In this study, we report the structure of the dimer, and the dynamics and thermodynamics of the dimerization.