To the bones: mapping the skeletal LEPR+ pool to component cell types

Abstract

Leptin receptor‐positive skeletal progenitors constitute an essential cell population in the bone, yet their heterogeneity remains incompletely understood. In this issue, Mo et al (2021) report a single‐cell RNA sequencing resource that deconvolutes the pool of LEPR+ skeletal cells under homeostatic and various pathologic conditions, uncovering context‐dependent contributions to diverse cell types and functions. A recent single‐cell sequencing resource uncovers diverse contributions of leptin receptor‐positive bone progenitors to skeletal cell populations.