Antiinflammation and Antioxidant Effect of Ethanolic Extract of Ageratum conyzoides Leaves

Abstract

Traditionally, Ageratum conyzoides is used to treat several inflammatory diseases, such as rheumatism and as wounds healing. This study aimed to evaluate the anti-inflammatory and antioxidant effects of 50% ethanol extract of A.conyzoides leaves. Anti-inflammatory assay was carried out in vivo using the 1% carrageenan induction method. The animals were divided into 5 groups, control, diclofenac sodium, extract at doses of 22.5, 45 and 90 mg/kg BW. Antioxidant activity was assayed by the DPPH method. The results showed that the extract at all doses gave an anti-inflammatory effect compared to the control (p<0.05), where the best results were given by extract doses of 45 and 90 mg/kg BW and equivalent to the comparison of diclofenac sodium (p>0.05). The results of the DPPH showed that the IC50 of the extract was 153.63 µg/ml and the antioxidant activity index value was 0.52 with moderate antioxidant activity. It is expected that antioxidant activity may play a role with anti-inflammatory effect of A.conyzoides ethanol extract.