A Novel and efficient synthesis of dronedarone hydrochloride, an antiarrhythmic drug substance

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Abstract

A novel and efficient synthesis of dronedarone hydrochloride starting from 2-n-butyl-5-nitrobenzofuran by employing mild and selective reaction conditions is described. The synthetic approach is operationally simple and suitable for industrial application.

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Mohanarangam, S., Satyanarayana, B., Elati, C. R., Vijayabhaskar, B., & Reddy, P. P. (2011). A Novel and efficient synthesis of dronedarone hydrochloride, an antiarrhythmic drug substance. Journal of the Chinese Chemical Society, 58(7), 841–845. https://doi.org/10.1002/jccs.201190133

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