New knowledge on the diagnosis of oral leukoplakia

Abstract

Introduction There have been many discussions and debates in the literature over appropriate criteria for diagnosing oral leukoplakia and for predicting its prognosis. Clinical aspects In general, two clinical variants of leukoplakia are being recognized: the homogeneous and non-homogeneous type. Clinical subdivisions of leukoplakia in these two types can be used for cases in -which no biopsy is available. Diagnostic procedures A 2-4 week interval to observe a possible regression or disappearance of a white lesion, after elimination of possible causative factors, seems to be a fully acceptable period of time before taking a biopsy. Taking a biopsy in homogeneous leukoplakia and espacially non-homogeneous leukoplakia should be a standard rule. It is recommended that the histologie report should include a statement on absence or presence of epithelial dysplasia and an assessment of its severity. This recommendation -was made in order to provide a classification and staging system reflecting the size and histopathologic findings. disappearance of a white lesion, after elimination of possible.U radu je dat pregled novijih saznanja vezanih za klinicku dijagnozu oralne leukoplakije. Najnoviji sistem klasifikacija stadijuma oralne leukoplakije zasniva se na odredjivanju velicine promen? i prisustvu ili odsustvu epitelne displazije. U slucaju da se biopsija ne moze uzeti, sistem dozvoljava da se histopatoloski nalaz zameni klinickom podelom na homogenu i nehomogenu. Prikazani sistem klasifikacije oralne leukoplakije treba da obezbedi uniformnost u iznosenju podataka, na osnovu kojih se mogu formirati stavovi u pogledu lecenja, komparacije efekata razlicitih terapijskih metoda, kao i podataka epidemioloskih studija.