Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr Virus or adenovirus after allogeneic stem cell transplantation

Abstract

Viral infections after allogeneic stem cell transplantation (SCT) are an important cause of morbidity and mortality as SCT can expose patients to a transient state of combined immunodeficieny. Most viral infections after SCT are caused by the endogenous reactivation of persistent pathogens such as adenovirus (ADV), cytomegalovirus (CMV), and Epstein-Barr-virus (EBV). The control of these infections will ultimately depend on the restoration of adequate T-cell immunity. © Georg Thieme Verlag KG Stuttgart, New York.