Antiproliferative activity of Acalypha Wilkesiana against human cervical cancer cell lines HeLa

Abstract

Cancer is still a problem and needs to be solved in all over the world. One of the most commen cancers which is experienced by women is cervical cancer. Therefore, alternative therapies derived from natural ingredients such as the sablo plant are needed that have the potential to be developed as an anti-cancer. This study evaluated the antiproliferative activity of the extract and fractions of sablo leaves to cervical cancer HeLa cells with Cell Counting Kit-8 (CCK-8). The results showed that ethanol extract, n-hexane fraction, butanol fraction, water fraction, and ethyl acetate fraction of sablo leaves had antiproliferative activity against HeLa cells, with an IC50 of 604.14 µg/mL, 1054.11 µg/mL, 219.44 µg/mL, 578.33 µg/mL, and 531.72 µg/mL, respectively. The results showed that sablo leaves from ethyl acetate fraction were the best fraction in inhibiting the proliferation of cervical cancer cells HeLa and had the potential to be developed in cancer treatment