CURRENT TRENDS IN TREATMENT AND MANAGEMENT OF PSORIASIS: AN UPDATED REVIEW

Abstract

Psoriasis is a proliferative autoimmune skin disease which is affecting 2% of worldwide population. It is characterized by itching, skin rashes and red scalps with white scales on the skin. Though, different types are reported, common existing form of psoriasis is plaque psoriasis. The epidemiology of disease seems to be remains unknown, but the incidence varies, surrounded by the different countries. The pathophysiology of the disease appears as drastic cellular changes occur both in epidermis and dermis which narrates to keratinocyte hyperproliferation. Earlier available medications like emollients and some keratolyitic agents has not proven promising role in controlling the disease burden. But, in advance regimen, with wide range of therapeutic mediators like coal tar, anthranilin, calcineurin inhibitors, methotrexate, retinoids, cyclosporine are proven to be effective in treating mild psoriasis to severe psoriasis. In recent years, phototherapy has once again emerged as most recommended due to ease of treatment and its intoxications. Hence, this review emphasizes the therapeutic agents available in market and its effectiveness in controlling the psoriasis.Copyright © 2018, International Research Journal of Pharmacy.