Diastereoselective three-component reactions of chiral nickel(ii) glycinate for convenient synthesis of novel a-Amino-ß-substituted disubstituted butyric acids

Abstract

The convenient, high yielding and diastereoselective synthesis of a-Amino-ß-substituted-,-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to a-Amino-ß-substituted-,- disubstituted butyric acid derivatives.