Hyalocytes in proliferative vitreo-retinal diseases

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Abstract

Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.

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Jones, C. H., Gui, W., Schumann, R. G., Boneva, S. K., Lange, C. A. K., van Overdam, K. A., … Sebag, J. (2022). Hyalocytes in proliferative vitreo-retinal diseases. Expert Review of Ophthalmology. Taylor and Francis Ltd. https://doi.org/10.1080/17469899.2022.2100764

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