Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis

Abstract

The EtOAc extract of a Taiwanese soft coral, Caldiella australis, yielded four new eunicellin-based diterpenoids, australins A-D (1-4). The chemical structures of these metabolites were determined on the basis of extensive spectroscopic (including ID and 2D NMR) analyses and by comparison of their NMR spectral data with those of related metabolites. Metabolite 2 was found to possess a moderate cytotoxic activity against selected breast and liver cancer cell lines. © 2005 American Chemical Society and American Society of Pharmacognosy.