Abstract
The solubility of Δ9-tetrahydrocannabinol (Δ9-THC) in supercritical carbon dioxide has been determined at 315, 327, 334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Δ9-THC ranged from 0.20 to 2.95 × 10-4. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD). © 2009 Elsevier B.V. All rights reserved.
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Perrotin-Brunel, H., Perez, P. C., van Roosmalen, M. J. E., van Spronsen, J., Witkamp, G. J., & Peters, C. J. (2010). Solubility of Δ9-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling. Journal of Supercritical Fluids, 52(1), 6–10. https://doi.org/10.1016/j.supflu.2009.12.001
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