Point-of-care testing for viral-associated pulmonary aspergillosis

9Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Introduction: Over the last years, severe respiratory viral infections, particularly those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the influenza virus, have emerged as risk factor for viral-associated pulmonary aspergillosis (VAPA) among critically ill patients. Delays in diagnosis of VAPA are associated with increased mortality. Point-of-care-tests may play an important role in earlier diagnosis of VAPA and thus improve patient outcomes. Areas covered: The following review will give an update on point-of-care tests for VAPA, analyzing performances in respiratory and blood specimens. Expert opinion: Point-of-care tests have emerged, and particularly the IMMY Aspergillus galactomannan lateral flow assay (LFA) shows performances comparable to the galactomannan ELISA for diagnosis of VAPA. Notably, nearly all evaluations of POC tests for VAPA have been performed in COVID-19 patients, with very limited data in influenza patients. For early diagnosis of COVID associated pulmonary aspergillosis (CAPA), the LFA has shown promising performances in respiratory samples, particularly in bronchoalveolar lavage fluid, and may thereby help in improving patient outcomes. In contrast, serum LFA testing may not be useful for early diagnosis of disease, except in cases with invasive tracheobronchial aspergillosis.

Cite

CITATION STYLE

APA

Aerts, R., Autier, B., Gornicec, M., Prattes, J., Lagrou, K., Gangneux, J. P., & Hoenigl, M. (2024). Point-of-care testing for viral-associated pulmonary aspergillosis. Expert Review of Molecular Diagnostics. Taylor and Francis Ltd. https://doi.org/10.1080/14737159.2023.2257597

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free