Effect of lumbar cistern drainage combined with nimodipine on cerebral vasospasm after intracranial aneurysm intervention

Abstract

The aim of the present study was to observe and analyze the effect of lumbar cistern drainage combined with nimodipine on cerebral vasospasm after intracranial aneurysm intervention. About 180 patients who underwent intracranial aneurysm intervention in the Second People's Hospital of Liaocheng were enrolled as research subjects. They were randomly divided into the research group and the control group, each containing 90 patients. The control group was subjected to combined therapy of nimodipine with intermittent lumbar puncture to release cerebrospinal fluid; while the research group was subjected to combined therapy of lumbar cistern drainage and nimodipine. The therapeutic effect in both groups of patients was observed and compared. The incidence rate of cerebral vasospasm was significantly lower in the research group when compared to the control group. The cerebrospinal fluid pressure and erythrocyte count on postoperative days 4, 8 and 12 was significantly lower in the research group. Both groups showed significant improvement after treatment, but the improvement in research group was more pronounced. By observing the degree of neurological defects between the 2 groups, the national institutes of health stroke scale score of the research group had significant advantages compared to that of the control group. For patients with intracranial aneurysm interventional therapy, the application of lumbar cistern drainage combined with nimodipine could achieve better results with greater safety.