Ferrioxamine excretion in iron-loaded man

Abstract

Factors affecting iron excretion after subcutaneous desferioxamine infusion were evaluated in individuals with iron overload. Urinary iron varied directly, whereas stool iron varied inversely with the level of erythropoiesis. Ascorbic acid greatly enhanced urinary excretion but had a less constant effect on stool iron. Stool iron losses contributed a greater proportion of total iron excretion at higher chelator dosage. These studies indicate the importance of biliary iron excretion in monitoring the effectiveness of desferrioxamine. They also suggest that large chelator doses may remove established iron overload much more rapidly than has been previously realized.