Pharmacokinetics of tylvalosin alone or in combination with vitamin E in broiler chickens

Abstract

Few publications are describing the pharmacokinetics of tylvalosin (TVN) antibiotic, so the aims of this work were to study its pharmacokinetics with evaluation the effect of vitamin (vit) E on its kinetics after single and repeated oral administration in broiler chickens. The mean serum concentrations of the drug were markedly lower in tylvalosin alone when compared with tylvalosin pre-treated with vit E after single and repeated oral administration at the corresponding time intervals. The peak of serum concentration (Cmax), absorption half-life (t0.5ab) and elimination half-life (t0.5 e-l) were 2.11±0.3, 3.27±0.2 ug mLG-1, 0.94±0.04, 0.88±0.02 h and 1.61±0.05, 2.42±0.1, after single tylvalosin and tylvalosin-vit E, respectively. While after repeated dosing, the maximum serum levels were 5.01±0.13 and 5.9±0.1 ug mLG-1 with pharmacokinetic parameters (Cmax), (t0.5ab) and (t0.5 el) 4.1±0.14, 5.67±0.4 ug mLG1, 1.39±0.4, 0.86±0.07 h and 2.78±0.16, 3.05±0.3 h after repeated tylvalosin and tylvalosin-vit E, respectively. The combination of tylvalosin with vit E allows a prolongation of the dosage intervals in broiler for more 12 and 24 h after single and repeated dosing, respectively, indicated by longer elimination half-life and Mean Residence Time (MRT) of tylvalosin-vit E than tylvalosin alone after single and repeated administration which is very important for the dosage intervaland increasing the drug serum efficacy.