Local Immunologic Response to Immunization with Inactivated Newcastle Disease Virus

Abstract

Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the intramuscular or intranasal route, and the appearance of HI antibodies in the serum and lungs was followed. Local secretory antibodies in the lung were found only as a consequence of intranasal immunization, whereas serum antibodies were found after administration of antigen by either route.