The Role of Iron in Parkinson Disease and 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Toxicity

Abstract

Parkinson disease (PD) involves the specific degeneration of dopaminergic neurons ofthe pars compacta ofthe substantia nigra. Although the cause of the degeneration of nigrostrial dopaminergic neurons in PD is unknown, there is significant evidence to suggest that oxidative stress may be involved in this process. This review specifically examines the current status of evidence suggesting iron may contribute to oxidative damage associated with PD.