Uji Efek Teratogen Anti Nyamuk Bakar yang Mengandung Transfluthrin terhadap Fetus Mencit Putih

Abstract

Teratogenic test of anti-mosquito coils containing transfluthrin has been conducted on fetus of laboratory mice. Pregnant mice had been given anti-mosquito exposure by inhalation of anti-mosquito coils smoke during the period of organogenesis which begins from the sixth to the fifteenth day of pregnancy. Laparactomy was conducted on the eighteenth day of pregnancy, then two-thirds of the fetus is immersed in a solution of red-alizarin and the remaining in Bouin's solution. The results showed that the fetus with two times of exposure to anti-mosquito coils smoke leads to resorption tread and slower fetal growth. At three times of exposure, showing slower fetal growth, fatality when the laparactomi was conducted, haemorrhage and anencephaly. At four times of the exposure can cause slower fetal growth, fatality on laparactomy and haemorrhage. Exposure to anti-mosquito coils smoke can also lead to reducing weight of the mice and fetus significantly. Keywords